Hypotensive effect of hydroxylamine, an endogenous nitric oxide donor and SSAO inhibitor.

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Vidrio H, Medina M

Hypotensive effect of hydroxylamine, an endogenous nitric oxide donor and SSAO inhibitor.

J Neural Transm (Vienna). 2007;114(6):863-5. Epub 2007 Mar 26.

PubMed ID

17385063 [ View in PubMed

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Abstract

The endogenous compound hydroxylamine relaxes vascular smooth muscle in vitro, apparently through conversion to the vasodilator factor nitric oxide, but its effect on blood pressure has not been characterized. We found that in the anesthetized rat the amine elicits dose-related hypotension when administered by continuous iv infusion. In experiments designed to explore the mechanism of this effect, hydroxylamine was compared with the nitric oxide donor nitroprusside and the direct-acting vasodilator hydralazine, using pretreatments known to modify diverse mechanisms of vasodilation. Hydroxylamine hypotension was enhanced by the SSAO inhibitor isoniazid and the SSAO substrate methylamine, a pattern shared by hydralazine. Responses were blocked by the guanylate cyclase inhibitor methylene blue and were increased by the nitric oxide synthase inhibitor L-NAME, a pattern shared by nitroprusside. It was concluded that hydroxylamine exerts hypotension partly through conversion to nitric oxide and partly by a "hydralazine-like" mechanism involving SSAO inhibition.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Hydralazine	Membrane primary amine oxidase	Protein	Humans	Yes	Inhibitor	Details