Structures of the human and Drosophila 80S ribosome.

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Anger AM, Armache JP, Berninghausen O, Habeck M, Subklewe M, Wilson DN, Beckmann R

Structures of the human and Drosophila 80S ribosome.

Nature. 2013 May 2;497(7447):80-5. doi: 10.1038/nature12104.

PubMed ID
23636399 [ View in PubMed
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Abstract

Protein synthesis in all cells is carried out by macromolecular machines called ribosomes. Although the structures of prokaryotic, yeast and protist ribosomes have been determined, the more complex molecular architecture of metazoan 80S ribosomes has so far remained elusive. Here we present structures of Drosophila melanogaster and Homo sapiens 80S ribosomes in complex with the translation factor eEF2, E-site transfer RNA and Stm1-like proteins, based on high-resolution cryo-electron-microscopy density maps. These structures not only illustrate the co-evolution of metazoan-specific ribosomal RNA with ribosomal proteins but also reveal the presence of two additional structural layers in metazoan ribosomes, a well-ordered inner layer covered by a flexible RNA outer layer. The human and Drosophila ribosome structures will provide the basis for more detailed structural, biochemical and genetic experiments.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
60S ribosomal protein L10-likeQ96L21Details
60S ribosomal protein L13aP40429Details
60S ribosomal protein L23P62829Details
60S ribosomal protein L15P61313Details
60S ribosomal protein L19P84098Details
60S ribosomal protein L23aP62750Details
60S ribosomal protein L8P62917Details
60S ribosomal protein L37P61927Details
60S ribosomal protein L3P39023Details
60S ribosomal protein L11P62913Details
Elongation factor 2P13639Details
40S ribosomal protein S2P15880Details
Receptor of activated protein C kinase 1P63244Details
60S ribosomal protein L14P50914Details
60S ribosomal protein L18Q07020Details
60S ribosomal protein L35P42766Details
60S ribosomal protein L4P36578Details
40S ribosomal protein S13P62277Details
40S ribosomal protein S17P08708Details
40S ribosomal protein S18P62269Details
40S ribosomal protein S19P39019Details
40S ribosomal protein S28P62857Details
40S ribosomal protein S5P46782Details
40S ribosomal protein S6P62753Details
40S ribosomal protein S8P62241Details
40S ribosomal protein S9P46781Details