Inositol monophosphatase regulates localization of synaptic components and behavior in the mature nervous system of C. elegans.

Article Details

Citation

Tanizawa Y, Kuhara A, Inada H, Kodama E, Mizuno T, Mori I

Inositol monophosphatase regulates localization of synaptic components and behavior in the mature nervous system of C. elegans.

Genes Dev. 2006 Dec 1;20(23):3296-310.

PubMed ID
17158747 [ View in PubMed
]
Abstract

Although recent studies have provided significant molecular insights into the establishment of neuronal polarity in vitro, evidence is lacking on the corresponding phenomena in vivo, including correct localization of synaptic components and the importance of this process for function of the nervous system as a whole. RIA interneurons act as a pivotal component of the neural circuit for thermotaxis behavior in the nematode Caenorhabditis elegans and provide a suitable model to investigate these issues, having a neurite clearly divided into pre- and post-synaptic regions. In a screen for thermotaxis mutants, we identified the gene ttx-7, which encodes myo-inositol monophosphatase (IMPase), an inositol-producing enzyme regarded as a bipolar disorder-relevant molecule for its lithium sensitivity. Here we show that mutations in ttx-7 cause defects in thermotaxis behavior and localization of synaptic proteins in RIA neurons in vivo. Both behavioral and localization defects in ttx-7 mutants were rescued by expression of IMPase in adults and by inositol application, and the same defects were mimicked by lithium treatment in wild-type animals. These results suggest that IMPase is required in central interneurons of the mature nervous system for correct localization of synaptic components and thus for normal behavior.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
Lithium carbonateInositol monophosphatase 1ProteinHumans
Unknown
Not AvailableDetails
Lithium cationInositol monophosphatase 1ProteinHumans
Unknown
Inhibitor
Details
Lithium citrateInositol monophosphatase 1ProteinHumans
Unknown
Not AvailableDetails
Lithium succinateInositol monophosphatase 1ProteinHumans
Unknown
Not AvailableDetails