The histamine H1-receptor antagonist binding site. Part I: Active conformation of cyproheptadine.

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van Drooge MJ, Donne-op den Kelder GM, Timmerman H

The histamine H1-receptor antagonist binding site. Part I: Active conformation of cyproheptadine.

J Comput Aided Mol Des. 1991 Aug;5(4):357-70.

PubMed ID

1686618 [ View in PubMed

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Abstract

The active conformation of several histamine H1-antagonists is investigated. As a template molecule we used the antagonist cyproheptadine, which consists of a piperidylene ring connected to a tricyclic system. The piperidylene moiety is shown to be flexible. The global minimum is a chair conformation but, additionally, a second chair and various boat conformations have to be considered, as their energies are less than 5 kcal/mol above the energy of the global minimum. Two semi-rigid histamine H1-antagonists, phenindamine and triprolidine, were fitted onto the various conformations of cyproheptadine in order to derive the pharmacologically active conformation of cyproheptadine. At the same time, the active conformation of both phenindamine and triprolidine was derived. It is demonstrated that, within the receptor-bound conformation of cyproheptadine, the piperidylene ring most probably exists in a boat form.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Phenindamine	Histamine H1 receptor	Protein	Humans	Yes	Antagonist	Details