Molecular cloning and tissue distribution of rat peptide transporter PEPT2.

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Saito H, Terada T, Okuda M, Sasaki S, Inui K

Molecular cloning and tissue distribution of rat peptide transporter PEPT2.

Biochim Biophys Acta. 1996 Apr 26;1280(2):173-7.

PubMed ID

8639691 [ View in PubMed

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Abstract

A cDNA encoding rat H(+)- coupled peptide transporter PEPT2 was isolated. The cDNA encoded a protein of 729 amino acids with 48% amino acid identity to the rat PEPT1. The mRNA expression of rat PEPT2 was predominant in the kidney. When expressed in Xenopus oocytes, rat PEPT2 stimulated the uptake of bestatin, a dipeptide-like drug.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Ubenimex	Bacterial leucyl aminopeptidase	Protein	Vibrio proteolyticus	Unknown	Not Available	Details

Drug Transporters

Drug	Transporter	Kind	Organism	Pharmacological Action	Actions
Ubenimex	Solute carrier family 15 member 1	Protein	Humans	Unknown	Inhibitor	Details
Ubenimex	Solute carrier family 15 member 2	Protein	Humans	Unknown	Substrate Inhibitor	Details