The primary structure of human platelet profilin: reinvestigation of the calf spleen profilin sequence.
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Ampe C, Markey F, Lindberg U, Vandekerckhove J
The primary structure of human platelet profilin: reinvestigation of the calf spleen profilin sequence.
FEBS Lett. 1988 Feb 8;228(1):17-21.
- PubMed ID
- 3342873 [ View in PubMed]
- Abstract
The primary structure of human platelet profilin was determined by aligning the sequences of its tryptic peptides to the previously determined calf spleen profilin sequence [(1979) FEBS Lett. 101, 161-165]. Comparison of the peptide fingerprints of the two proteins suggested a higher homology than that found by direct sequence comparison. We therefore reinvestigated the sequences of the peptides from calf spleen profilin. We identified four incorrect charge assignments and a deletion of three residues. The similarity between the two vertebrate profilins amounts to 95%.