Ca2+ channel sensitivity towards the blocker isradipine is affected by alternative splicing of the human alpha1C subunit gene.

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Zuhlke RD, Bouron A, Soldatov NM, Reuter H

Ca2+ channel sensitivity towards the blocker isradipine is affected by alternative splicing of the human alpha1C subunit gene.

FEBS Lett. 1998 May 8;427(2):220-4.

PubMed ID

9607315 [ View in PubMed

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Abstract

L-type Ca2+ channels are important targets for drugs, such as dihydropyridines (DHPs), in the treatment of cardiovascular diseases. Channel expression is regulated by alternative splicing. It has been suggested that in the cardiovascular system tissue-specific expression of different L-type Ca2+ channel splice variants may underlie the observed differences in sensitivities to channel block by DHPs. We investigated the sensitivity of Ca2+ channel splice variants derived from the human alpha1C gene to the DHP isradipine. Among seven alpha1C channels we observed up to 10-fold differences in IC50 values for isradipine, as well as changes in the voltage dependence of DHP action.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Isradipine	Voltage-dependent L-type calcium channel subunit alpha-1C	Protein	Humans	Yes	Inhibitor	Details

Polypeptides

Name	UniProt ID
Voltage-dependent L-type calcium channel subunit alpha-1C	Q13936	Details