Recent advances in the discovery of alpha1-adrenoceptor agonists.

Article Details

Citation

Bishop MJ

Recent advances in the discovery of alpha1-adrenoceptor agonists.

Curr Top Med Chem. 2007;7(2):135-45.

PubMed ID
17266602 [ View in PubMed
]
Abstract

The alpha(1) adrenoceptors are three of nine well-characterized receptors that are activated by epinephrine and norepinephrine. Agonists acting at the alpha(1) adrenoceptors produce numerous physiological effects, and are used therapeutically for several indications. Many known alpha(1) adrenoceptor agonists are alpha(1A) selective, but the discovery of highly selective alpha(1B) and alpha(1D) adrenoceptor agonists has proven to be an extremely difficult goal to achieve. This review will focus on recent advances in the discovery, development and clinical utility of subtype-specific alpha(1) agonists as well as contributions to our understanding of agonist-receptor interactions.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
DroxidopaAlpha-1A adrenergic receptorProteinHumans
Yes
Agonist
Details
DroxidopaAlpha-1B adrenergic receptorProteinHumans
Yes
Agonist
Details
DroxidopaAlpha-1D adrenergic receptorProteinHumans
Yes
Agonist
Details
NorepinephrineAlpha-1A adrenergic receptorProteinHumans
Yes
Agonist
Details
NorepinephrineAlpha-1B adrenergic receptorProteinHumans
Yes
Agonist
Details
NorepinephrineAlpha-1D adrenergic receptorProteinHumans
Yes
Agonist
Details