Beta-adrenergic stimulation and myocardial function in the failing heart.

Article Details

Citation

El-Armouche A, Eschenhagen T

Beta-adrenergic stimulation and myocardial function in the failing heart.

Heart Fail Rev. 2009 Dec;14(4):225-41. doi: 10.1007/s10741-008-9132-8.

PubMed ID
19110970 [ View in PubMed
]
Abstract

The sympathetic nervous system provides the most powerful stimulation of cardiac function, brought about via norepinephrine and epinephrine and their postsynaptic beta-adrenergic receptors. More than 30 years after the first use of practolol in patients with heart failure beta blockers are now the mainstay of the pharmacological treatment of chronic heart failure. Many aspects of their mechanism of action are well understood, but others remain unresolved. This review focuses on a number of questions that are key to further developments in the field. What accounts for and what is the role of beta-adrenergic desensitization, a hallmark of the failing heart? Is part of this adaptation predominantly beneficial and should therefore be reinforced, another part mainly maladaptive and therefore a target for antagonists? Which lessons can be drawn from studies in genetically engineered mice, which from (pharmaco) genetic studies? Finally, what are promising targets downstream of beta-adrenergic receptors that go beyond the current neurohumoral blockade?

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
DroxidopaBeta-1 adrenergic receptorProteinHumans
Yes
Agonist
Details
DroxidopaBeta-2 adrenergic receptorProteinHumans
Yes
Agonist
Details
DroxidopaBeta-3 adrenergic receptorProteinHumans
Yes
Agonist
Details
NorepinephrineBeta-1 adrenergic receptorProteinHumans
Yes
Agonist
Details
NorepinephrineBeta-2 adrenergic receptorProteinHumans
Yes
Agonist
Details