Stimulation of ciliary motility mediated by atypical beta-adrenoceptor in canine bronchial epithelium.

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Tamaoki J, Chiyotani A, Sakai N, Konno K

Stimulation of ciliary motility mediated by atypical beta-adrenoceptor in canine bronchial epithelium.

Life Sci. 1993;53(20):1509-15.

PubMed ID

8105356 [ View in PubMed

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Abstract

The effects of catecholamines on ciliary motility of canine bronchial epithelium was studied by a photoelectric method in vitro. Addition of beta-adrenoceptor agonists increased ciliary beat frequency, a rank order of potency being salbutamol > or = BRL 37344, a selective beta 3-adrenoceptor agonist > norepinephrine. The response to BRL 37344 was relatively resistant to the blockade of beta 1- and beta 2-adrenoceptors but was competitively antagonized by the beta 3-adrenoceptor antagonist cyanopindolol, with the pA2 value being lower than that when salbutamol was used as an agonist. These results suggest that beta 3-adrenoceptors exist in canine bronchial epithelium and that stimulation of this receptor subtype may enhance ciliary motility and, hence, mucociliary transport in the airway.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Norepinephrine	Beta-3 adrenergic receptor	Protein	Humans	Yes	Agonist	Details