Low-density lipoprotein receptor-related protein 1: new functions for an old molecule.

Article Details

Citation

Franchini M, Montagnana M

Low-density lipoprotein receptor-related protein 1: new functions for an old molecule.

Clin Chem Lab Med. 2011 Jun;49(6):967-70. doi: 10.1515/CCLM.2011.154. Epub 2011 Mar 11.

PubMed ID
21391865 [ View in PubMed
]
Abstract

The low-density lipoprotein receptor-related protein 1 (LRP1) is a multifunctional cell surface receptor member of the low-density lipoprotein (LDL)-receptor family. As LRP1 plays an important role in endocytosis and regulation of signalling pathways, it is implicated in a number of physiologic processes, including the regulation of lipid metabolism, the proliferation of vascular smooth muscle cells and in neuro-development. More recently, LRP1 has been implicated in the catabolism of factor VIII and regulation of its plasma concentrations. The pathophysiology of the role of LRP1 in hemostasis will be summarized in this review.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
Antihemophilic factor, human recombinantProlow-density lipoprotein receptor-related protein 1ProteinHumans
Unknown
Modulator
Details
Lonoctocog alfaProlow-density lipoprotein receptor-related protein 1ProteinHumans
Unknown
Modulator
Details
Moroctocog alfaProlow-density lipoprotein receptor-related protein 1ProteinHumans
Unknown
Modulator
Details