The clinical profile of the angiotensin II receptor blocker eprosartan.

Article Details

Citation

Copy to clipboard

Hedner T

The clinical profile of the angiotensin II receptor blocker eprosartan.

J Hypertens Suppl. 2002 Jun;20(5):S33-8.

PubMed ID

12184062 [ View in PubMed

]

Abstract

Angiotensin II receptor antagonists block angiotensin II type 1 (AT1) receptors and reduce the pressor effects of angiotensin in the vasculature. By this mechanism, they induce similar pharmacological effects to angiotensin-converting enzyme (ACE) inhibitors, resulting in a lowering of blood pressure (BP). However, AT1 antagonists differ from ACE inhibitors with respect to side effects, and induce less cough, which is related to bradykinin activation. Within the class of angiotensin II antagonists, eprosartan differs from other currently clinically available agents in terms of its chemical structure and its dual pharmacological mode of action. Eprosartan acts not only at vascular AT1 receptors but also at presynaptic AT1 receptors, causing inhibition of sympathetically stimulated noradrenaline release. Eprosartan is not metabolized by cytochrome P450 enzymes and therefore has a low potential for metabolic drug interactions, which may be of importance when treating the elderly and patients on multiple drugs. In clinical trials eprosartan has proven to be at least as effective as the ACE inhibitor enalapril in reducing BP, but with a significantly lower incidence of side effects. Eprosartan is safe, effective and well tolerated in long-term treatment, either as monotherapy or in combination with other antihypertensive drugs such as hydrochlorothiazide.

DrugBank Data that Cites this Article

Drugs

Eprosartan

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Eprosartan	Type-1 angiotensin II receptor	Protein	Humans	Yes	Antagonist	Details