Structure of the gene encoding the muscle-specific subunit of human phosphoglycerate mutase.

Article Details

Citation

Tsujino S, Sakoda S, Mizuno R, Kobayashi T, Suzuki T, Kishimoto S, Shanske S, DiMauro S, Schon EA

Structure of the gene encoding the muscle-specific subunit of human phosphoglycerate mutase.

J Biol Chem. 1989 Sep 15;264(26):15334-7.

PubMed ID
2549058 [ View in PubMed
]
Abstract

We report the isolation and analysis of genomic clones containing the entire gene encoding the muscle-specific subunit of human phosphoglycerate mutase. The gene spans 2.83 kilobase pairs and has a three-exon/two-intron structure that is similar to the organization of the human 2,3-bisphosphoglycerate mutase gene (Joulin, V., Garel, M.-C., LeBoulch, P., Valentin, C., Rosa, R., Rosa, J., and Cohen-Solal, M. (1988) J. Biol. Chem. 263, 15785-15790), in that the second introns of both genes are localized precisely at the same position. A canonical TATA box and an inverted CCAAT box are present immediately upstream of this gene. Comparison with other muscle-specific enzyme genes reveals a conserved 9-base pair element (GGGGCTGGG) in the 5'-flanking region that may be associated with the expression of genes encoding muscle-specific enzymes.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Phosphoglycerate mutase 2P15259Details