Surfactant protein A and B genetic variants predispose to idiopathic pulmonary fibrosis.
Article Details
- CitationCopy to clipboard
Selman M, Lin HM, Montano M, Jenkins AL, Estrada A, Lin Z, Wang G, DiAngelo SL, Guo X, Umstead TM, Lang CM, Pardo A, Phelps DS, Floros J
Surfactant protein A and B genetic variants predispose to idiopathic pulmonary fibrosis.
Hum Genet. 2003 Nov;113(6):542-50. Epub 2003 Sep 6.
- PubMed ID
- 13680361 [ View in PubMed]
- Abstract
Derangement in pulmonary surfactant or its components and alveolar collapse are common findings in idiopathic pulmonary fibrosis (IPF). Surfactant proteins play important roles in innate host defense and normal function of the lung. We examined associations between IPF and genetic polymorphic variants of surfactant proteins, SP-A1, SP-A2, SP-B, SP-C, and SP-D. One SP-A1 (6A(4)) allele and single nucleotide polymorphisms (SNPs) that characterize the 6A(4) allele, and one SP-B (B1580_C) were found with higher frequency ( P