Interaction between factor VIII and LDL receptor-related protein. Modulation of coagulation?
Article Details
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Neels JG, Bovenschen N, van Zonneveld AJ, Lenting PJ
Interaction between factor VIII and LDL receptor-related protein. Modulation of coagulation?
Trends Cardiovasc Med. 2000 Jan;10(1):8-14.
- PubMed ID
- 11150722 [ View in PubMed]
- Abstract
Recent reports suggest that the multifunctional receptor low-density lipoprotein receptor-related protein (LRP) may contribute to the regulation of blood coagulation by mechanisms that differ from the simple removal of protease/inhibitor complexes from the circulation. This possibility became apparent from the observation that LRP is involved in down-regulation of Tissue Factor expression at the surface of monocytes and fibroblasts. Furthermore, coagulation Factor VIII and activated Factor IX (Factor IXa) have been identified as proteins that are able to bind to LRP. In the present review, the potential contribution of LRP to the regulation of the coagulation cascade through these novel pathways is discussed, with particular reference to the interaction between LRP and coagulation Factor VIII.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Coagulation Factor IX (Recombinant) Coagulation factor VIII Protein Humans YesCofactorDetails Coagulation Factor IX Human Coagulation factor VIII Protein Humans YesCofactorDetails