Impact of growth hormone receptor blockade on substrate metabolism during fasting in healthy subjects.

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Moller L, Norrelund H, Jessen N, Flyvbjerg A, Pedersen SB, Gaylinn BD, Liu J, Thorner MO, Moller N, Lunde Jorgensen JO

Impact of growth hormone receptor blockade on substrate metabolism during fasting in healthy subjects.

J Clin Endocrinol Metab. 2009 Nov;94(11):4524-32. doi: 10.1210/jc.2009-0381. Epub 2009 Oct 9.

PubMed ID

19820031 [ View in PubMed

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Abstract

CONTEXT: Experimental studies in GH-deficient patients and in healthy subjects receiving somatostatin-infusion suggest that GH is an important regulator of substrate metabolism during fasting. These models may not adequately reflect the selective effects of GH, and GH receptor (GHR) blockade offers a new model to define the metabolic role of GH. OBJECTIVE: The aim of this study was to investigate the impact of GHR blockade on substrate metabolism and insulin sensitivity during fasting. DESIGN: We conducted a randomized, placebo-controlled, crossover study in 10 healthy young men. INTERVENTION: After 36 h of fasting with saline or pegvisomant (GHR blockade), the subjects were studied during a 4-h basal period and 2.5-h hyperinsulinemic euglycemic clamp. MAIN OUTCOME: We measured whole-body and forearm glucose, lipid, and protein metabolism, peripheral insulin sensitivity, and acyl and desacyl ghrelin. RESULTS: GHR blockade significantly suppressed circulating free fatty acids (1226 +/- 83 vs. 1074 +/- 65 micromol/liter; P = 0.03) and ketone bodies (3080 +/- 271 vs. 2015 +/- 235 micromol/liter; P

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Pegvisomant	Growth hormone receptor	Protein	Humans	Yes	Antagonist	Details