Oligomeric structure of the human EphB2 receptor SAM domain.

Article Details

Citation

Thanos CD, Goodwill KE, Bowie JU

Oligomeric structure of the human EphB2 receptor SAM domain.

Science. 1999 Feb 5;283(5403):833-6.

PubMed ID
9933164 [ View in PubMed
]
Abstract

The sterile alpha motif (SAM) domain is a protein interaction module that is present in diverse signal-transducing proteins. SAM domains are known to form homo- and hetero-oligomers. The crystal structure of the SAM domain from an Eph receptor tyrosine kinase, EphB2, reveals two large interfaces. In one interface, adjacent monomers exchange amino-terminal peptides that insert into a hydrophobic groove on each neighbor. A second interface is composed of the carboxyl-terminal helix and a nearby loop. A possible oligomer, constructed from a combination of these binding modes, may provide a platform for the formation of larger protein complexes.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Ephrin type-B receptor 2P29323Details