Oligomeric structure of the human EphB2 receptor SAM domain.
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Thanos CD, Goodwill KE, Bowie JU
Oligomeric structure of the human EphB2 receptor SAM domain.
Science. 1999 Feb 5;283(5403):833-6.
- PubMed ID
- 9933164 [ View in PubMed]
- Abstract
The sterile alpha motif (SAM) domain is a protein interaction module that is present in diverse signal-transducing proteins. SAM domains are known to form homo- and hetero-oligomers. The crystal structure of the SAM domain from an Eph receptor tyrosine kinase, EphB2, reveals two large interfaces. In one interface, adjacent monomers exchange amino-terminal peptides that insert into a hydrophobic groove on each neighbor. A second interface is composed of the carboxyl-terminal helix and a nearby loop. A possible oligomer, constructed from a combination of these binding modes, may provide a platform for the formation of larger protein complexes.