Trifluorothymidine induces cell death independently of p53.

Article Details

Citation

Copy to clipboard

Bijnsdorp IV, Kruyt FA, Fukushima M, Peters GJ

Trifluorothymidine induces cell death independently of p53.

Nucleosides Nucleotides Nucleic Acids. 2008 Jun;27(6):699-703. doi: 10.1080/15257770802145017.

PubMed ID

18600528 [ View in PubMed

]

Abstract

Trifluorothymidine (TFT), a potent anticancer agent, inhibits thymidylate synthase (TS) and is incorporated into the DNA, both events resulting in cell death. Cell death induction related to DNA damage often involves activation of p53. We determined the role of p53 in TFT cytotoxicity and cell death induction, using, respectively, the sulforhodamine B-assay and FACS analysis, in a panel of cell lines with either wild type, inactive, or mutated p53. Neither TFT cytotoxicity nor cell death induction changed with TFT exposure in cell lines with wt, inactive or mutated p53. CONCLUSION: sensitivity to TFT is not dependent on the expression of wt p53.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Trifluridine	DNA	Nucleotide	Humans	Yes	Other/unknown	Details
Trifluridine	Thymidylate synthase	Protein	Humans	Yes	Inhibitor	Details