Ran/TC4: a small nuclear GTP-binding protein that regulates DNA synthesis.

Article Details

Citation

Ren M, Drivas G, D'Eustachio P, Rush MG

Ran/TC4: a small nuclear GTP-binding protein that regulates DNA synthesis.

J Cell Biol. 1993 Jan;120(2):313-23.

PubMed ID
8421051 [ View in PubMed
]
Abstract

Ran/TC4, first identified as a well-conserved gene distantly related to H-RAS, encodes a protein which has recently been shown in yeast and mammalian systems to interact with RCC1, a protein whose function is required for the normal coupling of the completion of DNA synthesis and the initiation of mitosis. Here, we present data indicating that the nuclear localization of Ran/TC4 requires the presence of RCC1. Transient expression of a Ran/TC4 protein with mutations expected to perturb GTP hydrolysis disrupts host cell DNA synthesis. These results suggest that Ran/TC4 and RCC1 are components of a GTPase switch that monitors the progress of DNA synthesis and couples the completion of DNA synthesis to the onset of mitosis.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
GTP-binding nuclear protein RanP62826Details