CRM1 is an export receptor for leucine-rich nuclear export signals.

Article Details

Citation

Fornerod M, Ohno M, Yoshida M, Mattaj IW

CRM1 is an export receptor for leucine-rich nuclear export signals.

Cell. 1997 Sep 19;90(6):1051-60.

PubMed ID
9323133 [ View in PubMed
]
Abstract

CRM1 is distantly related to receptors that mediate nuclear protein import and was previously shown to interact with the nuclear pore complex. Overexpression of CRM1 in Xenopus oocytes stimulates Rev and U snRNA export from the nucleus. Conversely, leptomycin B, a cytotoxin that is shown to bind to CRM1 protein, specifically inhibits the nuclear export of Rev and U snRNAs. In vitro, CRM1 forms a leptomycin B-sensitive complex involving cooperative binding of both RanGTP and the nuclear export signal (NES) from either the Rev or PKI proteins. We conclude that CRM1 is an export receptor for leucine-rich nuclear export signals and discuss a model for the role of RanGTP in CRM1 function and in nuclear export in general.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
GTP-binding nuclear protein RanP62826Details
Exportin-1O14980Details