Reshaping human antibodies for therapy.

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Riechmann L, Clark M, Waldmann H, Winter G

Reshaping human antibodies for therapy.

Nature. 1988 Mar 24;332(6162):323-7.

PubMed ID
3127726 [ View in PubMed
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Abstract

A human IgGI antibody has been reshaped for serotherapy in humans by introducing the six hypervariable regions from the heavy- and light-chain variable domains of a rat antibody directed against human lymphocytes. The reshaped human antibody is as effective as the rat antibody in complement and is more effective in cell-mediated lysis of human lymphocytes.

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