An investigation of the 5-HT2C receptor gene as a migraine candidate gene.

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Johnson MP, Lea RA, Curtain RP, MacMillan JC, Griffiths LR

An investigation of the 5-HT2C receptor gene as a migraine candidate gene.

Am J Med Genet B Neuropsychiatr Genet. 2003 Feb;117B(1):86-9.

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12555241 [ View in PubMed

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Abstract

Migraine is a common complex disorder, currently classified into two main subtypes, migraine with aura (MA) and migraine without aura (MO). The strong preponderance of females to males suggests an X-linked genetic component. Recent studies have identified an X chromosomal susceptibility region (Xq24-q28) in two typical migraine pedigrees. This region harbours a potential candidate gene for the disorder, the serotonin receptor 2C (5-HT(2C)) gene. This study involved a linkage and association approach to investigate two single nucleotide variants in the 5-HT(2C) gene. In addition, exonic coding regions of the 5-HT(2C) gene were also sequenced for mutations in X-linked migraine pedigrees. Results of this study did not detect any linkage or association, and no disease causing mutations were identified. Hence, results for this study do not support a significant role of the 5-HT(2C) gene in migraine predisposition.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Methysergide	5-hydroxytryptamine receptor 2C	Protein	Humans	Yes	Antagonist	Details