The potential for xanthine oxidase inhibition in the prevention and treatment of cardiovascular and cerebrovascular disease.

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Higgins P, Dawson J, Walters M

The potential for xanthine oxidase inhibition in the prevention and treatment of cardiovascular and cerebrovascular disease.

Cardiovasc Psychiatry Neurol. 2009;2009:282059. doi: 10.1155/2009/282059. Epub 2009 Nov 4.

PubMed ID

20029618 [ View in PubMed

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Abstract

There is a now a wealth of epidemiological, animal, and clinical data to suggest the benefits of uric acid reduction and hxanthine oxidase inhibition in prevention of vascular disease. This review discusses the available epidemiological, preclinical, and clinical data and considers arguments for and against a role for serum uric acid in common cardiovascular disorders. It concludes that large scale trials with clinical endpoints are justified to address this important question and to define whether use of drugs such as allopurinol should be a routine part of preventative strategies.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Allopurinol	Xanthine dehydrogenase/oxidase	Protein	Humans	Yes	Inhibitor	Details