Altered membrane permeability as the basis of bactericidal action of methdilazine.

Article Details

Citation

Chattopadhyay D, Mukherjee T, Pal P, Saha B, Bhadra R

Altered membrane permeability as the basis of bactericidal action of methdilazine.

J Antimicrob Chemother. 1998 Jul;42(1):83-6.

PubMed ID
9700532 [ View in PubMed
]
Abstract

The growth inhibition of Escherichia coli and Staphylococcus aureus was accompanied by significant release of K+ and UV-absorbing small molecules upon exposure to methdilazine, an extensively used phenothiazine antihistamine. A severe decrease in [U-14C] glucose uptake and a rapid efflux of hexose from sugar-preloaded bacteria were also observed but without visible cellular lysis. Considerable damage to membrane permeability by methdilazine was proposed to explain the rapid loss in cfu/mL of the bacteria.

DrugBank Data that Cites this Article

Drugs
Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
MethdilazineHistamine H1 receptorProteinHumans
Yes
Antagonist
Details