A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB.
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DiDonato JA, Hayakawa M, Rothwarf DM, Zandi E, Karin M
A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB.
Nature. 1997 Aug 7;388(6642):548-54.
- PubMed ID
- 9252186 [ View in PubMed]
- Abstract
Nuclear transcription factors of the NF-kappaB/Rel family are inhibited by IkappaB proteins, which inactivate NF-kappaB by trapping it in the cell cytoplasm. Phosphorylation of IkappaBs marks them out for destruction, thereby relieving their inhibitory effect on NF-kappaB. A cytokine-activated protein kinase complex, IKK (for IkappaB kinase), has now been purified that phosphorylates IkappaBs on the sites that trigger their degradation. A component of IKK was molecularly cloned and identified as a serine kinase. IKK turns out to be the long-sought-after protein kinase that mediates the critical regulatory step in NF-kappaB activation.