The differential contribution of arginase and transamidinase to ornithine biosynthesis in two achromic human melanoma cell lines.

Article Details

Citation

Thomasset N, Quash GA, Dore JF

The differential contribution of arginase and transamidinase to ornithine biosynthesis in two achromic human melanoma cell lines.

FEBS Lett. 1982 Nov 1;148(1):63-6.

PubMed ID
7173402 [ View in PubMed
]
Abstract

Cellular ornithine biosynthesis could be expected to play a significant role in putrescine formation and hence in growth. Two enzymes are involved in ornithine biosynthesis: arginase and transamidinase. These enzyme activities were studied in two human melanoma cell lines differing in their Km of diamine oxidase for putrescine and in their tumorigenicity in nude mice. Arginase activity accounts for the majority of ornithine formed in the highly tumorigenic cell line, while the majority of ornithine is derived from transamidinase action in the poorly tumorigenic cell line, with concomitant formation of methyl guanidine, a potent inhibitor of diamine oxidase.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
OrnithineGlycine amidinotransferase, mitochondrialProteinHumans
Unknown
Not AvailableDetails