Amino acid sequence of a polymorphic segment from fragment C4d of human complement component C4.

Article Details

Citation

Chakravarti DN, Campbell RD, Gagnon J

Amino acid sequence of a polymorphic segment from fragment C4d of human complement component C4.

FEBS Lett. 1983 Apr 18;154(2):387-90.

PubMed ID
6832377 [ View in PubMed
]
Abstract

The amino acid sequence of a segment of 106 residues of C4d has been determined by automated sequence analysis of fragments obtained by CNBr cleavage and enzymic digestion with trypsin. Polymorphism has been detected at 3 positions. Residues 9 and 12 are either valine and leucine or alanine and arginine, respectively. Residue 102 is either valine or arginine. When comparing the protein sequence with the nucleic, acid sequence [Carroll, M. and Porter, R.R. (1983) Proc. Natl. Acad. Sci. USA 80, in press] alanine or serine are found at position 98. These results may in part help to explain the inherited variants of human C4 seen on gel electrophoresis.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Complement C4-AP0C0L4Details
Complement C4-BP0C0L5Details