Amino acid sequence of a polymorphic segment from fragment C4d of human complement component C4.
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Chakravarti DN, Campbell RD, Gagnon J
Amino acid sequence of a polymorphic segment from fragment C4d of human complement component C4.
FEBS Lett. 1983 Apr 18;154(2):387-90.
- PubMed ID
- 6832377 [ View in PubMed]
- Abstract
The amino acid sequence of a segment of 106 residues of C4d has been determined by automated sequence analysis of fragments obtained by CNBr cleavage and enzymic digestion with trypsin. Polymorphism has been detected at 3 positions. Residues 9 and 12 are either valine and leucine or alanine and arginine, respectively. Residue 102 is either valine or arginine. When comparing the protein sequence with the nucleic, acid sequence [Carroll, M. and Porter, R.R. (1983) Proc. Natl. Acad. Sci. USA 80, in press] alanine or serine are found at position 98. These results may in part help to explain the inherited variants of human C4 seen on gel electrophoresis.