c-Raf kinase binds to N-terminal domain of c-Myc.

Article Details

Citation

Alexandrov I, Shlyakhova L, Vartanian A, Zajac-Kaye M, Alexandrova N

c-Raf kinase binds to N-terminal domain of c-Myc.

FEBS Lett. 1997 Sep 8;414(2):465-70.

PubMed ID
9315742 [ View in PubMed
]
Abstract

We have demonstrated that the 50 N-terminal amino acids of c-Myc bind a kinase activity, which phosphorylates Myc in vitro predominantly on Thr8. We also have shown that c-Raf, a widely known Ser/Thr kinase, involved in the Ras signaling pathway, binds to the same portion of c-Myc in vitro. In addition we were able to precipitate native c-Myc/Raf complex from various cell lysates. Physical interaction of Myc and Raf may potentially be a part of their well-known functional cooperation.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Myc proto-oncogene proteinP01106Details