Identification and functional expression of a receptor selectively recognizing parathyroid hormone, the PTH2 receptor.
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Usdin TB, Gruber C, Bonner TI
Identification and functional expression of a receptor selectively recognizing parathyroid hormone, the PTH2 receptor.
J Biol Chem. 1995 Jun 30;270(26):15455-8.
- PubMed ID
- 7797535 [ View in PubMed]
- Abstract
We have identified a G-protein-coupled receptor specifically activated by parathyroid hormone, which we refer to as the PTH2 receptor. Parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP, hypercalcemia of malignancy factor) activate a previously identified PTH/PTHrP receptor, which has a widespread tissue distribution. The PTH2 receptor is much more selective in ligand recognition and appears to have a more specific tissue distribution. It is activated by PTH and not by PTHrP and is particularly abundant in the brain and pancreas.