Zonisamide has beneficial effects on Parkinson's disease patients.

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Murata M, Horiuchi E, Kanazawa I

Zonisamide has beneficial effects on Parkinson's disease patients.

Neurosci Res. 2001 Dec;41(4):397-9.

PubMed ID

11755227 [ View in PubMed

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Abstract

Zonisamide (ZNS) is a generally well tolerated anticonvulsant that has beneficial effects on Parkinson's disease (PD). ZNS (300 mg/day) given to a patient with PD who incidentally had convulsive attacks, ameliorated the attacks and, surprisingly, his parkinsonian symptoms. We, therefore, carried out an open trial of ZNS on nine patients with PD. Patients were given 50-200 mg/day ZNS in addition to their anti-PD drugs. Seven clearly showed lessening of symptoms, especially wearing-off. We speculate that long lasting activation of dopamine synthesis by ZNS ameliorates parkinsonian symptoms, in particular wearing-off.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Zonisamide	Amine oxidase [flavin-containing] B	Protein	Humans	Unknown	Inhibitor	Details