TMEM16A protein: a new identity for Ca(2+)-dependent Cl(-) channels.
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Ferrera L, Caputo A, Galietta LJ
TMEM16A protein: a new identity for Ca(2+)-dependent Cl(-) channels.
Physiology (Bethesda). 2010 Dec;25(6):357-63. doi: 10.1152/physiol.00030.2010.
- PubMed ID
- 21186280 [ View in PubMed]
- Abstract
Ca(+)-dependent Cl(-) channels (CaCCs) play a variety of physiological roles in different organs and tissues, including transepithelial Cl(-) secretion, smooth muscle contraction, regulation of neuronal excitability, and transduction of sensory stimuli. The recent identification of TMEM16A protein as an important component of CaCCs should allow a better understanding of their physiological role, structure-function relationship, and regulatory mechanisms.