ErbB4/HER4: role in mammary gland development, differentiation and growth inhibition.

Article Details

Citation

Muraoka-Cook RS, Feng SM, Strunk KE, Earp HS 3rd

ErbB4/HER4: role in mammary gland development, differentiation and growth inhibition.

J Mammary Gland Biol Neoplasia. 2008 Jun;13(2):235-46. doi: 10.1007/s10911-008-9080-x. Epub 2008 Apr 25.

PubMed ID
18437540 [ View in PubMed
]
Abstract

The ErbB receptor tyrosine kinase family has often been associated with increased growth of breast epithelial cells, as well as malignant transformation and progression. In contrast, ErbB4/HER4 exhibits unique attributes from a two step proteolytic cleavage which releases an 80 kilodalton, nuclear localizing, tyrosine kinase to a signal transduction mechanism that slows growth and stimulates differentiation of breast cells. This review provides an overview of ErbB4/HER4 in growth and differentiation of the mammary epithelium, including its physiologic role in development, the contrasting growth inhibition/tumor suppression and growth acceleration of distinct ErbB4/HER4 isoforms and a description of the unique cell cycle regulated pattern of nuclear HER4 ubiquitination and destruction.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Receptor tyrosine-protein kinase erbB-4Q15303Details