Alpha-tocopherol as a modulator of smooth muscle cell proliferation.

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Azzi A, Boscoboinik D, Clement S, Marilley D, Ozer NK, Ricciarelli R, Tasinato A

Alpha-tocopherol as a modulator of smooth muscle cell proliferation.

Prostaglandins Leukot Essent Fatty Acids. 1997 Oct;57(4-5):507-14.

PubMed ID
9430404 [ View in PubMed
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Abstract

The effects of alpha-tocopherol and beta-tocopherol have been studied in rat and human aortic smooth muscle cells. Alpha-tocopherol, but not beta-tocopherol, inhibited smooth muscle cell proliferation and protein kinase C in a dose-dependent manner, at concentrations ranging from 10 to 50 microM. Beta-tocopherol added simultaneously with alpha-tocopherol prevented both proliferation and protein kinase C inhibition. Protein kinase C inhibition was cell cycle-dependent and it was prevented by okadaic acid, a protein phosphatase inhibitor. Protein kinase C activity measured from aortas of cholesterol-fed rabbits was also inhibited by alpha-tocopherol. By using protein kinase C (PKC) isoform-specific inhibitors and immunoprecipitation reactions it was found that PKC-alpha was selectively inhibited by alpha-tocopherol. Further, an activation of protein phosphatase 2A by alpha-tocopherol was found, which caused PKC-alpha dephosphorylation and inhibition. Ultimately, this cascade of events at the level of cell signal transduction leads to the inhibition of smooth muscle cell proliferation.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
alpha-Tocopherol succinateProtein kinase C alpha typeProteinHumans
Unknown
Not AvailableDetails
D-alpha-Tocopherol acetateProtein kinase C alpha typeProteinHumans
Unknown
Not AvailableDetails
Vitamin EProtein kinase C alpha typeProteinHumans
Unknown
Not AvailableDetails