The haploinsufficient tumor suppressor p18 upregulates p53 via interactions with ATM/ATR.

Article Details

Citation

Park BJ, Kang JW, Lee SW, Choi SJ, Shin YK, Ahn YH, Choi YH, Choi D, Lee KS, Kim S

The haploinsufficient tumor suppressor p18 upregulates p53 via interactions with ATM/ATR.

Cell. 2005 Jan 28;120(2):209-21.

PubMed ID
15680327 [ View in PubMed
]
Abstract

p18 was first identified as a factor associated with a macromolecular tRNA synthetase complex. Here we describe the mouse p18 loss-of-function phenotype and a role for p18 in the DNA damage response. Inactivation of both p18 alleles caused embryonic lethality, while heterozygous mice showed high susceptibility to spontaneous tumors. p18 was induced and translocated to the nucleus in response to DNA damage. Expression of p18 resulted in elevated p53 levels, while p18 depletion blocked p53 induction. p18 directly interacted with ATM/ATR in response to DNA damage. The activity of ATM was dependent on the level of p18, suggesting the requirement of p18 for the activation of ATM. Low p18 expression was frequently observed in different human cancer cell lines and tissues. These results suggest that p18 is a haploinsufficient tumor suppressor and a key factor for ATM/ATR-mediated p53 activation.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Serine-protein kinase ATMQ13315Details
Serine/threonine-protein kinase ATRQ13535Details