Molecular mechanisms of glucocorticoid receptor signaling.

Article Details

Citation

Copy to clipboard

Labeur M, Holsboer F

Molecular mechanisms of glucocorticoid receptor signaling.

Medicina (B Aires). 2010;70(5):457-62.

PubMed ID

20920967 [ View in PubMed

]

Abstract

This review highlights the most recent findings on the molecular mechanisms of the glucocorticoid receptor (GR). Most effects of glucocorticoids are mediated by the intracellular GR which is present in almost every tissue and controls transcriptional activation via direct and indirect mechanisms. Nevertheless the glu-cocorticoid responses are tissue -and gene- specific. GR associates selectively with corticosteroid ligands produced in the adrenal gland in response to changes of humoral homeostasis. Ligand interaction with GR promotes either GR binding to genomic glucocorticoid response elements, in turn modulating gene transcription, or interaction of GR monomers with other transcription factors activated by other signalling pathways leading to transrepression. The GR regulates a broad spectrum of physiological functions, including cell differentiation, metabolism and inflammatory responses. Thus, disruption or dysregulation of GR function will result in severe impairments in the maintenance of homeostasis and the control of adaptation to stress.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Alclometasone	Glucocorticoid receptor	Protein	Humans	Yes	Agonist	Details
Flumethasone	Glucocorticoid receptor	Protein	Humans	Yes	Agonist	Details