Dopamine uptake inhibiting versus dopamine releasing properties of fencamfamine: an in vitro study.

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Seyfried CA

Dopamine uptake inhibiting versus dopamine releasing properties of fencamfamine: an in vitro study.

Biochem Pharmacol. 1983 Aug 1;32(15):2329-31.

PubMed ID

6136281 [ View in PubMed

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Abstract

To elucidate its mechanism of action, the effects of fencamfamine, a norcamphanethylamine derivative, were studied in vitro on the release of newly accumulated dopamine in superfusion experiments using slices of rat corpus striatum and substantia nigra in comparison to nomifensine and d-amphetamine. Furthermore, the activity of fencamfamine on biogenic amine uptake in synaptosome preparations and on monoamine oxidase activity was evaluated. As compared to d-amphetamine, fencamfamine exhibited roughly 10 times less dopamine releasing activity in striatal slices at concentrations at which dopamine uptake into synaptosomes was almost completely blocked although, at high concentrations, what was probably non-specific release due to interactions with neuronal membranes could also be demonstrated. In addition, fencamfamine, unlike d-amphetamine did not inhibit monoamine oxidase. It is concluded that, at least in the models employed, the in vitro profile of fencamfamine is more similar to that of nomifensine, a reportedly pure uptake inhibitor, than to d-amphetamine.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Fencamfamin	Sodium-dependent dopamine transporter	Protein	Humans	Yes	Inhibitor	Details