The interaction between coumarin drugs and DNA gyrase.

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Maxwell A

The interaction between coumarin drugs and DNA gyrase.

Mol Microbiol. 1993 Aug;9(4):681-6.

PubMed ID

8231802 [ View in PubMed

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Abstract

The coumarin group of antibiotics have as their target the bacterial enzyme DNA gyrase. The drugs bind to the B subunit of gyrase and inhibit DNA supercoiling by blocking the ATPase activity. Recent data show that the binding site for the drugs lies within the N-terminal part of the B protein, and individual amino acids involved in coumarin interaction are being identified. The mode of inhibition of the gyrase ATPase reaction by coumarins is unlikely to be simple competitive inhibition, and the drugs may act by stabilizing a conformation of the enzyme with low affinity for ATP.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Novobiocin	DNA gyrase subunit B	Protein	Staphylococcus aureus	Yes	Inhibitor	Details