Dopamine D2(High) receptors moderately elevated by sertindole.

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Seeman P

Dopamine D2(High) receptors moderately elevated by sertindole.

Synapse. 2008 May;62(5):389-93. doi: 10.1002/syn.20498.

PubMed ID

18293356 [ View in PubMed

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Abstract

Because long-term administration of antipsychotics can cause behavioral dopamine supersensitivity, this study examined whether the antipsychotic sertindole could elicit biochemical changes indicative of dopamine supersensitivity. In rats, behavioral dopamine supersensitivity is consistently associated with an increased proportion of dopamine receptors that have high affinity for dopamine, namely D2(High), in homogenized striata. Nine days of subcutaneously injected sertindole (1.25 mg/kg/day) increased the proportion of D2(High) receptors between 186% and 215%, although the total population of D2 receptors did not change. Although the findings suggest that rats or patients treated with sertindole might exhibit behavioral dopamine supersensitivity, the drug-induced increase in D2(High) receptors was less than that previously found with haloperidol.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Sertindole	Dopamine D2 receptor	Protein	Humans	Yes	Antagonist	Details