alpha2delta and the mechanism of action of gabapentin in the treatment of pain.

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Maneuf YP, Luo ZD, Lee K

alpha2delta and the mechanism of action of gabapentin in the treatment of pain.

Semin Cell Dev Biol. 2006 Oct;17(5):565-70. Epub 2006 Sep 24.

PubMed ID

17067834 [ View in PubMed

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Abstract

Gabapentin is a drug that has been widely used in the treatment of chronic pain states. Despite its widespread usage, it is only recently that light has been shed on the mechanism of action of this agent. In the current review, the authors document the pharmacological, biochemical and molecular information that has led to the identification of the alpha2delta1 auxilliary subunit of voltage gated calcium channels as the target for this drug's actions.

DrugBank Data that Cites this Article

Drugs

Gabapentin

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Gabapentin	Voltage-dependent calcium channel subunit alpha-2/delta-1	Protein	Humans	Yes	Inhibitor	Details