Chemoprevention of severe neonatal hyperbilirubinemia.

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Drummond GS, Kappas A

Chemoprevention of severe neonatal hyperbilirubinemia.

Semin Perinatol. 2004 Oct;28(5):365-8.

PubMed ID
15686268 [ View in PubMed
]
Abstract

The uses of synthetic heme analogues that are competitive inhibitors of heme oxygenase, the rate-limiting enzyme in the production of bilirubin, represent a novel means of controlling severe hyperbilirubinemia in the newborn. The logic of this approach and the use of stannsoporfin (tin mesoporphyrin) as the compound of choice are discussed.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
StannsoporfinHeme oxygenase 1ProteinHumans
Unknown
Not AvailableDetails
StannsoporfinHeme oxygenase 2ProteinHumans
Unknown
Not AvailableDetails