Serotonin and serotoninergic agents affect proliferation of normal and transformed lymphoid cells.

Article Details

Citation

Copy to clipboard

Smejkal-Jagar L, Boranic M

Serotonin and serotoninergic agents affect proliferation of normal and transformed lymphoid cells.

Immunopharmacol Immunotoxicol. 1995 Feb;17(1):151-62.

PubMed ID

7759768 [ View in PubMed

]

Abstract

Blastogenic transformation of murine spleen cells elicited with concanavalin A was suppressed by serotonin 10(-12) to 10(-6) M, and marginally stimulated by its antagonists ketanserin and propranolol in low concentrations (10(-15) to 10(-11) M). Ketanserin (5-HT2 receptor ligand) and propranolol (5-HT1A and beta-adrenergic ligand) did not block the suppressive effect of serotonin if used along with it in equimolar concentrations (10(-9) M). Ergot-alkaloid dihydroergosine suppressed, whereas dihydroergotoxin stimulated the blastogenic transformation. Opposite effects of the agents were obtained in experiments with mouse myeloma X63/Ag 8.653 and hybridoma SHV 125 cell lines, which unlike normal lymphoid cells, are homologous cell populations and proliferate spontaneously. The data indicate that serotonin and its antagonists interfere directly with mitosis and/or autocrine stimulation of target cells.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Propranolol	5-hydroxytryptamine receptor 1A	Protein	Humans	Unknown	Other/unknown	Details