Impaired pressure sensation in mice lacking TRPV4.

Article Details


Suzuki M, Mizuno A, Kodaira K, Imai M

Impaired pressure sensation in mice lacking TRPV4.

J Biol Chem. 2003 Jun 20;278(25):22664-8. Epub 2003 Apr 13.

PubMed ID
12692122 [ View in PubMed

The sensation of pressure, mechanosensation, in vertebrates remains poorly understood on the molecular level. The ion channel TRPV4 is in the TRP family and is a candidate for a mechanosensitive calcium-permeable channel. It is located in dorsal root ganglia. In the present study, we show that disrupting the Trpv4 gene in mice markedly reduced the sensitivity of the tail to pressure and acidic nociception. The threshold to noxious stimuli and the conduction velocity of myelinated nerve responding to stimuli were also impaired. Activation of unmyelinated nerve was undetected. However, the mouse still retained olfaction, taste sensation, and heat avoidance. The TRPV4 channel expressed in vitro in Chinese hamster ovary cells was opened by low pH, citrate, and inflation but not by heat or capsaicin. These data identify the TRPV4 channel as essential for the normal detection of pressure and as a receptor of the high-threshold mechanosensory complex.

DrugBank Data that Cites this Article

NameUniProt ID
Transient receptor potential cation channel subfamily V member 4Q9HBA0Details