Mode of action of pentavalent antimonials: specific inhibition of type I DNA topoisomerase of Leishmania donovani.

Article Details

Citation

Chakraborty AK, Majumder HK

Mode of action of pentavalent antimonials: specific inhibition of type I DNA topoisomerase of Leishmania donovani.

Biochem Biophys Res Commun. 1988 Apr 29;152(2):605-11.

PubMed ID
2835038 [ View in PubMed
]
Abstract

Sodium stibogluconate and Ureastibamine, two potent antileishmanial drugs specifically inhibit the relaxation of supercoiled plasmid pBR322 catalyzed by DNA topoisomerase I of Leishmania donovani. Dose dependent inhibition suggests that the drugs interact with the enzyme rather than the DNA. The inhibition reported here concerning a type I DNA topoisomerase demonstrates at least one possible mode of action of these antileishmanial drugs.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
Sodium stibogluconateDNA topoisomerase 1ProteinHumans
Yes
Inhibitor
Details