Mode of action of pentavalent antimonials: specific inhibition of type I DNA topoisomerase of Leishmania donovani.
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Chakraborty AK, Majumder HK
Mode of action of pentavalent antimonials: specific inhibition of type I DNA topoisomerase of Leishmania donovani.
Biochem Biophys Res Commun. 1988 Apr 29;152(2):605-11.
- PubMed ID
- 2835038 [ View in PubMed]
- Abstract
Sodium stibogluconate and Ureastibamine, two potent antileishmanial drugs specifically inhibit the relaxation of supercoiled plasmid pBR322 catalyzed by DNA topoisomerase I of Leishmania donovani. Dose dependent inhibition suggests that the drugs interact with the enzyme rather than the DNA. The inhibition reported here concerning a type I DNA topoisomerase demonstrates at least one possible mode of action of these antileishmanial drugs.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Sodium stibogluconate DNA topoisomerase 1 Protein Humans YesInhibitorDetails