The nuclear chloride ion channel NCC27 is involved in regulation of the cell cycle.

Article Details

Citation

Valenzuela SM, Mazzanti M, Tonini R, Qiu MR, Warton K, Musgrove EA, Campbell TJ, Breit SN

The nuclear chloride ion channel NCC27 is involved in regulation of the cell cycle.

J Physiol. 2000 Dec 15;529 Pt 3:541-52.

PubMed ID
11195932 [ View in PubMed
]
Abstract

NCC27 is a nuclear chloride ion channel, identified in the PMA-activated U937 human monocyte cell line. NCC27 mRNA is expressed in virtually all cells and tissues and the gene encoding NCC27 is also highly conserved. Because of these factors, we have examined the hypothesis that NCC27 is involved in cell cycle regulation. Electrophysiological studies in Chinese hamster ovary (CHO-K1) cells indicated that NCC27 chloride conductance varied according to the stage of the cell cycle, being expressed only on the plasma membrane of cells in G2/M phase. We also demonstrate that Cl- ion channel blockers known to block NCC27 led to arrest of CHO-K1 cells in the G2/M stage of the cell cycle, the same stage at which this ion channel is selectively expressed on the plasma membrane. These data strongly support the hypothesis that NCC27 is involved, in some as yet undetermined manner, in regulation of the cell cycle.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Chloride intracellular channel protein 1O00299Details