Ziprasidone: a novel antipsychotic agent with a unique human receptor binding profile.

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Schmidt AW, Lebel LA, Howard HR Jr, Zorn SH

Ziprasidone: a novel antipsychotic agent with a unique human receptor binding profile.

Eur J Pharmacol. 2001 Aug 17;425(3):197-201.

PubMed ID

11513838 [ View in PubMed

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Abstract

Ziprasidone is a novel antipsychotic agent with a unique combination of pharmacological activities at human receptors. Ziprasidone has high affinity for human 5-HT receptors and for human dopamine D(2) receptors. Ziprasidone is a 5-HT(1A) receptor agonist and an antagonist at 5-HT(2A), 5-HT(2C) and 5-HT(1B/1D) receptors. Additionally, ziprasidone inhibits neuronal uptake of 5-HT and norepinephrine comparable to the antidepressant imipramine. This unique pharmacological profile of ziprasidone may be related to its clinical effectiveness as a treatment for the positive, negative and affective symptoms of schizophrenia with a low propensity for extrapyramidal side effects, cognitive deficits and weight gain.

DrugBank Data that Cites this Article

Drugs

Ziprasidone

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Ziprasidone	5-hydroxytryptamine receptor 1A	Protein	Humans	Yes	Agonist	Details
Ziprasidone	5-hydroxytryptamine receptor 1B	Protein	Humans	Unknown	Antagonist	Details