mechanisms of disulfiram-induced cocaine abstinence: antabuse and cocaine relapse.

Article Details

Citation

Gaval-Cruz M, Weinshenker D

mechanisms of disulfiram-induced cocaine abstinence: antabuse and cocaine relapse.

Mol Interv. 2009 Aug;9(4):175-87. doi: 10.1124/mi.9.4.6.

PubMed ID
19720750 [ View in PubMed
]
Abstract

The anti-alcoholism drug disulfiram (Antabuse), which is an inhibitor of aldehyde dehydrogenase, induces an aversive reaction to alcohol consumption and thereby helps patients reduce alcohol intake. Recent clinical trials, initiated to investigate whether disulfiram could be used to treat individuals who abuse both alcohol and cocaine, have indicated that disulfiram effectively decreases cocaine consumption. Yet the ability of disulfiram to curb cocaine intake cannot be explained by the disruption of ethanol metabolism. Here, we synthesize clinical and animal data that point to dopamine beta-hydroxylase inhibition as a mechanism underlying the efficacy of disulfiram in the treatment of cocaine dependence.

DrugBank Data that Cites this Article

Drugs
Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
DisulfiramDopamine beta-hydroxylaseProteinHumans
Yes
Inhibitor
Details