Targeted therapy in renal cell carcinoma.

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Patard JJ, Pouessel D, Bensalah K, Culine S

Targeted therapy in renal cell carcinoma.

World J Urol. 2008 Apr;26(2):135-40. doi: 10.1007/s00345-008-0237-4. Epub 2008 Feb 12.

PubMed ID

18265991 [ View in PubMed

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Abstract

OBJECTIVE: To present an update on anti-angiogenic drugs in the treatment of metastatic renal cell carcinoma. RECENT FINDINGS: A better understanding of molecular pathways that are involved in clear cell carcinomas has led to the development of multiple targeted therapies with significant clinical benefits. Two tyrosine kinase inhibitors targeting the vascular endothelial growth factor (VEGF) receptor have been shown to improve the progression-free survival of patients in first-line (Sunitinib vs. interferon-alpha) or second-line treatment (Sorafenib vs. placebo). Temsirolimus, an agent that inhibits the serine-threonine kinase activity of the mammalian target of rapamycin, offers better overall survival than interferon in patients with poor-risk characteristics. Finally, Bevacizumab, which is an antibody directed against VEGF, in association with IFN is providing substantial response rates and increased progression-free survival compared to IFN alone. CONCLUSION: Four major drugs or regimens with proven efficacy are now available in first and second line therapy in metastatic renal cell carcinoma (mRCC). Further studies are needed to determine the optimal combinations of these agents in metastatic disease and to assess their impact in the adjuvant setting.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Temsirolimus	Serine/threonine-protein kinase mTOR	Protein	Humans	Yes	Inhibitor	Details