Human P450 metabolism of warfarin.
Article Details
- CitationCopy to clipboard
Kaminsky LS, Zhang ZY
Human P450 metabolism of warfarin.
Pharmacol Ther. 1997;73(1):67-74. doi: 10.1016/s0163-7258(96)00140-4.
- PubMed ID
- 9014207 [ View in PubMed]
- Abstract
The anticoagulant drug warfarin occurs as a pair of enantiomers that are differentially metabolized by human cytochromes P450 (CYP). R-warfarin is metabolized primarily by CYP1A2 to 6- and 8-hydroxywarfarin, by CYP3A4 to 10-hydroxywarfarin, and by carbonyl reductases to diastereoisomeric alcohols. S-warfarin is metabolized primarily by CYP2C9 to 7-hydroxywarfarin. Potential warfarin-drug interactions could occur with any of a very wide range of drugs that are metabolized by these P450s, and a number of such interactions have been reported. The efficacy of warfarin is affected primarily when metabolism of S-warfarin is altered.
DrugBank Data that Cites this Article
- Drug Enzymes
Drug Enzyme Kind Organism Pharmacological Action Actions (R)-warfarin Cytochrome P450 1A1 Protein Humans UnknownSubstrateDetails (R)-warfarin Cytochrome P450 1A2 Protein Humans UnknownSubstrateDetails (R)-warfarin Cytochrome P450 2C18 Protein Humans UnknownSubstrateDetails (R)-warfarin Cytochrome P450 2C19 Protein Humans UnknownSubstrateDetails (R)-warfarin Cytochrome P450 2C8 Protein Humans UnknownSubstrateDetails (R)-warfarin Cytochrome P450 2C9 Protein Humans UnknownSubstrateDetails (R)-warfarin Cytochrome P450 3A4 Protein Humans UnknownSubstrateDetails (S)-Warfarin Cytochrome P450 2C18 Protein Humans UnknownSubstrateDetails (S)-Warfarin Cytochrome P450 2C8 Protein Humans UnknownSubstrateDetails (S)-Warfarin Cytochrome P450 2C9 Protein Humans UnknownSubstrateDetails - Drug Interactions
Drugs Interaction Integrate drug-drug
interactions in your softwareAcenocoumarolImatinib Imatinib may increase the anticoagulant activities of Acenocoumarol. AcenocoumarolMethylene blue The serum concentration of Acenocoumarol can be increased when it is combined with Methylene blue. AcenocoumarolEtoricoxib The serum concentration of Acenocoumarol can be increased when it is combined with Etoricoxib. AcenocoumarolDronabinol The serum concentration of Acenocoumarol can be increased when it is combined with Dronabinol. AcenocoumarolAldesleukin The serum concentration of Acenocoumarol can be increased when it is combined with Aldesleukin. - Food Interactions
Drug Interaction (R)-warfarin Exercise caution with grapefruit products. Grapefruit inhibits CYP3A4 metabolism, which may increase the serum levels of R-warfarin. (R)-warfarin Exercise caution with St. John's Wort. This herb induces CYP3A4 metabolism, which may reduce the serum levels of R-warfarin.