Clinical pharmacology and pharmacogenetics of gemcitabine.

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Wong A, Soo RA, Yong WP, Innocenti F

Clinical pharmacology and pharmacogenetics of gemcitabine.

Drug Metab Rev. 2009;41(2):77-88. doi: 10.1080/03602530902741828.

PubMed ID

19514966 [ View in PubMed

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Abstract

Gemcitabine is a cytotoxic nucleoside analog, which is widely used in the treatment of malignancies. Interindividual differences in gemcitabine pharmacokinetics and pharmacodynamics have been demonstrated. Pharmacogenetic factors may account for a significant proportion of these differences. This review provides an update on the pharmacogenetics of gemcitabine and its influence on gemcitabine efficacy and toxicity.

DrugBank Data that Cites this Article

Drug Enzymes

Drug	Enzyme	Kind	Organism	Pharmacological Action	Actions
Gemcitabine	Cytidine deaminase	Protein	Humans	Unknown	Substrate	Details
Gemcitabine	Deoxycytidine kinase	Protein	Humans	Unknown	Substrate	Details