Denileukin diftitox: a biotherapeutic paradigm shift in the treatment of lymphoid-derived disorders.
Article Details
- CitationCopy to clipboard
Turturro F
Denileukin diftitox: a biotherapeutic paradigm shift in the treatment of lymphoid-derived disorders.
Expert Rev Anticancer Ther. 2007 Jan;7(1):11-7.
- PubMed ID
- 17187516 [ View in PubMed]
- Abstract
Denileukin diftitox (Ontak) represents an example of a fused molecule that targets cells bearing high affinity interleukin-2 receptors internalized via receptor-mediated endocytosis in an acidified vesicle. Denileukin diftitox is proteolytically cleaved within the endosome liberating the enzymatically active portion of the diphtheria toxin, the A fragment. Diphtheria toxin fragment A is released into the cytosol inhibiting the protein synthesis through the ADP-ribosylation of the elongation factor-2, and leading to cell death. This review focuses on the clinical trials that led to the FDA approval of the drug for cutaneous T cell lymphoma in the US, and investigational studies demonstrating drug-activity against B and T-cell non-Hodgkin's lymphoma, chronic lymphocytic lymphoma and acute graft versus disease within allogeneic hematopoietic stem cell transplant.
DrugBank Data that Cites this Article
- Drugs
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Denileukin diftitox Interleukin-2 receptor subunit alpha Protein Humans YesBinderDetails Denileukin diftitox Interleukin-2 receptor subunit beta Protein Humans YesAgonistDetails